SPPL2B

SPPL2B
Identifiers
Aliases	SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B
External IDs	OMIM: 608239; MGI: 1920468; HomoloGene: 10605; GeneCards: SPPL2B; OMA:SPPL2B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	2,355,095 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,704,542 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; left testis; ; right testis; ; right hemisphere of cerebellum; ; transverse colon; ; right lobe of thyroid gland; ; body of pancreas; ; left lobe of thyroid gland; ; mucosa of transverse colon;
	Top expressed in
	spermatocyte; ; fetal liver hematopoietic progenitor cell; ; spermatid; ; motor neuron; ; saccule; ; neural layer of retina; ; otic vesicle; ; otic placode; ; external carotid artery; ; Rostral migratory stream;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; aspartic-type endopeptidase activity; peptidase activity; protein binding; hydrolase activity; aspartic endopeptidase activity, intramembrane cleaving;
Cellular component	integral component of membrane; endosome; centrosome; Golgi apparatus; membrane; integral component of cytoplasmic side of endoplasmic reticulum membrane; Golgi membrane; nucleoplasm; lysosomal membrane; actin cytoskeleton; Golgi-associated vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; endosome membrane; plasma membrane;
Biological process	membrane protein proteolysis; proteolysis; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; regulation of immune response; regulation of tumor necrosis factor-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	56928
	73218
	ENSG00000005206
	ENSMUSG00000035206
	Q8TCT7
	Q3TD49
	NM_001077238; NM_152988
	NM_175195; NM_001358803; NM_001358804
	NP_001070706; NP_694533
	NP_780404; NP_001345732; NP_001345733
	Wikidata
View/Edit Human	View/Edit Mouse

Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.

This gene is a member of the signal peptide peptidase-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This enzyme localizes to endosomes, lysosomes, and the plasma membrane. This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells. SPPL2b also modulates APP cleavage and Aβ production. Multiple transcript variants encoding different isoforms have been found for this gene.