SPRY1

SPRY1
Identifiers
Aliases	SPRY1, hsprouty RTK signaling antagonist 1
External IDs	OMIM: 602465; MGI: 1345139; HomoloGene: 4266; GeneCards: SPRY1; OMA:SPRY1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	123,403,760 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	37,698,747 bp
RNA expression pattern
	Top expressed in
	pericardium; ; vena cava; ; gallbladder; ; parietal pleura; ; epithelium of colon; ; subcutaneous adipose tissue; ; canal of the cervix; ; skin of leg; ; left uterine tube; ; left lobe of thyroid gland;
	Top expressed in
	secondary oocyte; ; tail of embryo; ; lip; ; primary oocyte; ; lung; ; esophagus; ; quadriceps femoris muscle; ; right kidney; ; zone of skin; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi apparatus; membrane; plasma membrane; nucleoplasm; cytoplasm; cytosol;
Biological process	ureteric bud development; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; organ induction; bud elongation involved in lung branching; negative regulation of Ras protein signal transduction; multicellular organism development; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of GTPase activity; regulation of signal transduction; negative regulation of MAP kinase activity; establishment of mitotic spindle orientation; metanephros development; negative regulation of cell population proliferation; negative regulation of ERK1 and ERK2 cascade; epithelial to mesenchymal transition involved in cardiac fibroblast development;
	Sources:Amigo / QuickGO
Orthologs
	10252
	24063
	ENSG00000164056
	ENSMUSG00000037211
	O43609
	Q9QXV9
	NM_001258038; NM_001258039; NM_005841; NM_199327; NM_001375410
	NM_011896; NM_001305440; NM_001305441; NM_001305442
	NP_001244967; NP_001244968; NP_005832; NP_955359; NP_001362339
	NP_001292369; NP_001292370; NP_001292371; NP_036026
	Wikidata
View/Edit Human	View/Edit Mouse

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.