SPRY2

SPRY2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BUM, 3OB1
Identifiers
Aliases	SPRY2, hIGAN3, sprouty RTK signaling antagonist 2
External IDs	OMIM: 602466; MGI: 1345138; HomoloGene: 4267; GeneCards: SPRY2; OMA:SPRY2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	80,341,126 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	106,134,253 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; tibial nerve; ; right hemisphere of cerebellum; ; left uterine tube; ; ventricular zone; ; pericardium; ; parotid gland; ; right lung; ; right ventricle; ; retinal pigment epithelium;
	Top expressed in
	primary motor cortex; ; blastocyst; ; morula; ; cingulate gyrus; ; deep cerebellar nuclei; ; lateral geniculate nucleus; ; retinal pigment epithelium; ; olfactory tubercle; ; epiblast; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase inhibitor activity; protein serine/threonine kinase activator activity; protein binding; protein kinase binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; plasma membrane; ruffle membrane; microtubule; cytoskeleton; nucleus; microtubule cytoskeleton;
Biological process	cell fate commitment; negative regulation of neurotrophin TRK receptor signaling pathway; positive regulation of protein kinase B signaling; negative regulation of epidermal growth factor receptor signaling pathway; lung morphogenesis; lung development; bud elongation involved in lung branching; negative regulation of peptidyl-threonine phosphorylation; lung growth; negative regulation of apoptotic process; hearing; positive regulation of peptidyl-serine phosphorylation; negative regulation of Ras protein signal transduction; multicellular organism development; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; negative regulation of GTPase activity; regulation of cell population proliferation; regulation of signal transduction; negative regulation of MAP kinase activity; inner ear morphogenesis; respiratory system development; establishment of mitotic spindle orientation; negative regulation of cell projection organization; positive regulation of ERK1 and ERK2 cascade; regulation of cell differentiation; branching morphogenesis of an epithelial tube; negative regulation of cell population proliferation; positive regulation of protein serine/threonine kinase activity; positive regulation of cell migration; negative regulation of ERK1 and ERK2 cascade; cellular response to leukemia inhibitory factor; negative regulation of angiogenesis; cellular response to vascular endothelial growth factor stimulus; negative regulation of vascular endothelial growth factor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10253
	24064
	ENSG00000136158
	ENSMUSG00000022114
	O43597
	Q9QXV8
	NM_005842; NM_001318536; NM_001318537; NM_001318538
	NM_011897
	NP_001305465; NP_001305466; NP_001305467; NP_005833
	NP_036027
	Wikidata
View/Edit Human	View/Edit Mouse

Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the SPRY2 gene.