Sepiapterin reductase

SPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z6Z, 4HWK, 4J7U, 4J7X, 4XWY, 4Z3K
Identifiers
Aliases	SPR, SDR38C1, sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase), sepiapterin reductase
External IDs	OMIM: 182125; MGI: 103078; HomoloGene: 37735; GeneCards: SPR; OMA:SPR - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	72,892,158 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	85,114,748 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; apex of heart; ; body of pancreas; ; left adrenal gland; ; left adrenal cortex; ; body of stomach; ; human kidney;
	Top expressed in
	right kidney; ; ankle joint; ; human kidney; ; yolk sac; ; muscle of thigh; ; left lobe of liver; ; proximal tubule; ; lip; ; mucous cell of stomach; ; choroid plexus of fourth ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sepiapterin reductase activity; aldo-keto reductase (NADP) activity; NADP binding; oxidoreductase activity;
Cellular component	nucleoplasm; extracellular exosome; cytoplasm; cytosol;
Biological process	nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity; tetrahydrobiopterin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	6697
	20751
	ENSG00000116096
	ENSMUSG00000033735
	P35270
	Q64105
	NM_003124
	NM_011467
	NP_003115
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene.