SPTLC2

SPTLC2
Identifiers
Aliases	SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a, serine palmitoyltransferase long chain base subunit 2
External IDs	OMIM: 605713; MGI: 108074; HomoloGene: 21610; GeneCards: SPTLC2; OMA:SPTLC2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	77,616,637 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	87,435,129 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; inferior ganglion of vagus nerve; ; internal globus pallidus; ; monocyte; ; subthalamic nucleus; ; C1 segment; ; stromal cell of endometrium; ; buccal mucosa cell; ; pars reticulata; ; blood;
	Top expressed in
	decidua; ; gastrula; ; genital tubercle; ; granulocyte; ; duodenum; ; tail of embryo; ; ileum; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; catalytic activity; serine C-palmitoyltransferase activity; pyridoxal phosphate binding; acyltransferase activity;
Cellular component	integral component of membrane; serine C-palmitoyltransferase complex; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; mitochondrion;
Biological process	lipid metabolism; sphinganine biosynthetic process; sphingosine biosynthetic process; sphingolipid biosynthetic process; biosynthesis; sphingomyelin biosynthetic process; positive regulation of lipophagy; metabolism; ceramide biosynthetic process; sphingolipid metabolic process; adipose tissue development;
	Sources:Amigo / QuickGO
Orthologs
	9517
	20773
	ENSG00000100596
	ENSMUSG00000021036
	O15270
	P97363
	NM_004863
	NM_011479
	NP_004854; NP_004854.1
	NP_035609
	Wikidata
View/Edit Human	View/Edit Mouse

Serine palmitoyltransferase, long chain base subunit 2, also known as SPTLC2, is a protein which in humans is encoded by the SPTLC2 gene. SPTLC2 belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.