Serglycin

SRGN
Identifiers
Aliases	SRGN, PPG, PRG, PRG1, serglycin
External IDs	OMIM: 177040; MGI: 97756; HomoloGene: 2043; GeneCards: SRGN; OMA:SRGN - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	69,104,805 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,363,230 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; bone marrow; ; monocyte; ; bone marrow cells; ; blood; ; appendix; ; periodontal fiber; ; pericardium; ; endothelial cell; ; granulocyte;
	Top expressed in
	gastrula; ; decidua; ; granulocyte; ; blood; ; tibiofemoral joint; ; right lung lobe; ; dermis; ; bone marrow; ; cervix; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi apparatus; extracellular region; platelet alpha granule lumen; extracellular space; mast cell granule; Schaffer collateral - CA1 synapse; glutamatergic synapse; postsynaptic specialization, intracellular component;
Biological process	negative regulation of bone mineralization; biomineral tissue development; platelet degranulation; protease localization to mast cell secretory granule; granzyme-mediated apoptotic signaling pathway; apoptotic process; protein processing; mast cell secretory granule organization; T cell secretory granule organization; maintenance of protease location in mast cell secretory granule; maintenance of granzyme B location in T cell secretory granule; modulation of chemical synaptic transmission; regulation of postsynapse organization;
	Sources:Amigo / QuickGO
Orthologs
	5552
	19073
	ENSG00000122862
	ENSMUSG00000020077
	P10124
	P13609
	NM_002727; NM_001321053; NM_001321054
	NM_011157; NM_001358965
	NP_001307982; NP_001307983; NP_002718
	NP_035287; NP_001345894
	Wikidata
View/Edit Human	View/Edit Mouse

Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene. It is primarily expressed in hematopoietic cells and endothelial cells, and is the only known intracellular proteoglycan.