Sarcalumenin

SRL
Identifiers
Aliases	SRL, entrez:6345, sarcalumenin, SAR
External IDs	OMIM: 604992; MGI: 2146620; HomoloGene: 45500; GeneCards: SRL; OMA:SRL - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	4,242,080 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,359,680 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; myocardium of left ventricle; ; Skeletal muscle tissue of rectus abdominis; ; apex of heart; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; cardiac muscle tissue of right atrium; ; right auricle of heart; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	interventricular septum; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; temporal muscle; ; vastus lateralis muscle; ; extraocular muscle; ; muscle of thigh; ; medial head of gastrocnemius muscle; ; ankle; ; digastric muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTP binding;
Cellular component	sarcoplasmic reticulum; sarcoplasmic reticulum lumen;
Biological process	store-operated calcium entry; response to muscle activity involved in regulation of muscle adaptation;
	Sources:Amigo / QuickGO
Orthologs
	6345
	106393
	ENSG00000185739
	ENSMUSG00000022519
	Q86TD4
	Q7TQ48
	NM_001098814; NM_001323667; NM_001323668
	NM_175347; NM_001347162; NM_001361474
	NP_001092284; NP_001310596; NP_001310597
	NP_001334091; NP_780556; NP_001348403
	Wikidata
View/Edit Human	View/Edit Mouse

Sarcalumenin is a protein that in humans is encoded by the SRL gene.

Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle. Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins. Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity. Sarcalumenin is a calcium-binding glycoprotein composed of 473 acidic amino acids with a molecular weight of 160 KDa. Together along with other luminal calcium buffer proteins, sarcalumenin plays an important role in regulation of calcium uptake and release during excitation-contraction coupling (ECC) in muscle fibers.