SRSF2

SRSF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KN4, 2LEA, 2LEB, 2LEC
Identifiers
Aliases	SRSF2, PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b, serine/arginine-rich splicing factor 2, serine and arginine rich splicing factor 2
External IDs	OMIM: 600813; MGI: 98284; HomoloGene: 37721; GeneCards: SRSF2; OMA:SRSF2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,737,333 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,853,094 bp
RNA expression pattern
	Top expressed in
	tibia; ; embryo; ; tendon of biceps brachii; ; thymus; ; ventricular zone; ; ganglionic eminence; ; granulocyte; ; male germ cell; ; sperm; ; lymph node;
	Top expressed in
	corneal stroma; ; otic placode; ; tail of embryo; ; otic vesicle; ; Ileal epithelium; ; superior surface of tongue; ; genital tubercle; ; medial ganglionic eminence; ; saccule; ; lactiferous gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; protein binding; nucleic acid binding; RNA binding; protein kinase C binding; pre-mRNA binding;
Cellular component	PML body; nuclear speck; nucleoplasm; extracellular exosome; nucleus; cytosol; spliceosomal complex; interchromatin granule; cytoplasm;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA export from nucleus; RNA splicing; mRNA 3'-end processing; RNA export from nucleus; negative regulation of nucleic acid-templated transcription; mitotic cell cycle; regulation of alternative mRNA splicing, via spliceosome; response to vitamin E; regulation of RNA splicing; mRNA cis splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6427
	20382
	ENSG00000161547
	ENSMUSG00000034120
	Q01130
	Q62093
	NM_001195427; NM_003016
	NM_011358
	NP_001182356; NP_003007
	NP_035488
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene. MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.