Ohio State Route 159

State Route 159
Route information
Maintained by ODOT
Length30.91 mi (49.74 km)
Existed1923–present
Major junctions
South end
US 23 Bus. / US 50 / SR 104 in Chillicothe
Major intersections
North end US 22 near Lancaster
Location
CountryUnited States
StateOhio
CountiesRoss, Pickaway, Fairfield
Highway system
  • Ohio State Highway System
SR 158 SR 160

State Route 159 (SR 159) is a northeast-southwest state highway (signed northsouth) in the south-central portion of the U.S. state of Ohio. Its southern terminus is in Chillicothe at the U.S. Route 50 and State Route 104 concurrency; its northern terminus is at U.S. Route 22 approximately 4 miles (6.4 km) southwest of Lancaster.