SSH2

SSH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NT2
Identifiers
Aliases	SSH2, SSH-2, SSH-2L, slingshot protein phosphatase 2
External IDs	OMIM: 606779; MGI: 2679255; HomoloGene: 14116; GeneCards: SSH2; OMA:SSH2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	29,930,276 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	77,351,046 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; cardiac muscle tissue of right atrium; ; blood; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle; ; white blood cell;
	Top expressed in
	spermatocyte; ; extraocular muscle; ; digastric muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; interventricular septum; ; soleus muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; lymph node;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; actin binding; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity;
Cellular component	cytoplasm; cytoskeleton; extracellular space;
Biological process	regulation of lamellipodium assembly; regulation of axonogenesis; regulation of actin polymerization or depolymerization; protein dephosphorylation; peptidyl-tyrosine dephosphorylation; actin cytoskeleton organization; dephosphorylation; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	85464
	237860
	ENSG00000141298
	ENSMUSG00000037926
	Q76I76
	Q5SW75
	NM_001282129; NM_001282130; NM_001282131; NM_033389
	NM_001291190; NM_177710
	NP_001269058; NP_001269059; NP_001269060; NP_203747
	NP_001278119; NP_808378
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]