ST6GAL1

ST6GAL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JS1, 4JS2
Identifiers
Aliases	ST6GAL1, SIAT1, ST6GalI, ST6N, ST6 beta-galactoside alpha-2,6-sialyltransferase 1, CDw75
External IDs	OMIM: 109675; MGI: 108470; HomoloGene: 2281; GeneCards: ST6GAL1; OMA:ST6GAL1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	187,078,553 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	23,179,100 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; renal medulla; ; lymph node; ; bone marrow cells; ; epithelium of nasopharynx; ; nasal epithelium; ; urethra; ; bronchus; ; epithelium of bronchus;
	Top expressed in
	sciatic nerve; ; utricle; ; iris; ; Rostral migratory stream; ; condyle; ; Paneth cell; ; motor neuron; ; primitive streak; ; left lung lobe; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; protein binding; sialyltransferase activity; beta-galactoside alpha-2,6-sialyltransferase activity; protein homodimerization activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi cisterna membrane; extracellular region; Golgi membrane;
Biological process	sialylation; protein glycosylation; humoral immune response; O-glycan processing; oligosaccharide metabolic process; N-acetylneuraminate metabolic process; protein N-linked glycosylation via asparagine;
	Sources:Amigo / QuickGO
Orthologs
	6480
	20440
	ENSG00000073849
	ENSMUSG00000022885
	P15907
	Q64685
	NM_003032; NM_173216; NM_173217; NM_001353916
	NM_001252505; NM_001252506; NM_145933
	NP_003023; NP_775323; NP_775324; NP_001340845
	NP_001239434; NP_001239435; NP_666045
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found for this gene.

Transcripts of ST6GAL1 are found in mouse high endothelial cells of mesenteric lymph node and Peyer's patches, and it could be involved in the B cell homing to Peyer's patches. ST6GAL1 expression has also shown to be upregulated in several types of cancers and has been shown to haves roles in cancer survival and metastasis.