STAG3 (gene)

STAG3
Identifiers
Aliases	STAG3, stromal antigen 3, SPGF61
External IDs	OMIM: 608489; MGI: 1355311; HomoloGene: 40844; GeneCards: STAG3; OMA:STAG3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,221,488 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	138,310,655 bp
RNA expression pattern
	Top expressed in
	oocyte; ; right testis; ; left testis; ; secondary oocyte; ; right uterine tube; ; right hemisphere of cerebellum; ; C1 segment; ; gonad; ; gastrocnemius muscle; ; body of pancreas;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; Gonadal ridge; ; morula; ; embryo; ; blastocyst; ; zygote; ; embryo; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	chromatin binding; protein binding;
Cellular component	synaptonemal complex; meiotic cohesin complex; chromosome, centromeric region; nucleus; chromosome; extracellular space; chromatin; cohesin complex;
Biological process	cell cycle; meiosis; synaptonemal complex assembly; chromosome segregation; sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	10734
	50878
	ENSG00000066923
	ENSMUSG00000036928
	Q9UJ98
	O70576
	NM_001282716; NM_001282717; NM_001282718; NM_012447; NM_001375438
	NM_016964
	NP_001269645; NP_001269646; NP_001269647; NP_036579; NP_001362367
	NP_058660
	Wikidata
View/Edit Human	View/Edit Mouse

Stromal antigen 3 is a protein that in humans is encoded by the STAG3 gene. STAG3 protein is a component of a cohesin complex that regulates the separation of sister chromatids specifically during meiosis. STAG3 appears to be paramount in sister-chromatid cohesion throughout the meiotic process in human oocytes and spermatocytes.