STAP1

STAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X1F, 3MAZ
Identifiers
Aliases	STAP1, BRDG1, STAP-1, signal transducing adaptor family member 1
External IDs	OMIM: 604298; MGI: 1926193; HomoloGene: 8103; GeneCards: STAP1; OMA:STAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,607,337 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,253,984 bp
RNA expression pattern
	Top expressed in
	lymph node; ; epithelium of nasopharynx; ; spleen; ; appendix; ; granulocyte; ; bone marrow cells; ; testicle; ; tonsil; ; superficial temporal artery; ; blood;
	Top expressed in
	granulocyte; ; thymus; ; spleen; ; mesenteric lymph nodes; ; olfactory epithelium; ; blood; ; lumbar spinal ganglion; ; subcutaneous adipose tissue; ; tibiofemoral joint; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	macrophage colony-stimulating factor receptor binding; transmembrane receptor protein tyrosine kinase adaptor activity; phosphotyrosine residue binding; receptor tyrosine kinase binding; protein binding; phospholipid binding; protein kinase binding; signaling adaptor activity;
Cellular component	cytoplasm; mitochondrion; nucleus; nucleoplasm; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	positive regulation of B cell receptor signaling pathway; positive regulation of phagocytosis, engulfment; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of ruffle assembly; positive regulation of microglial cell mediated cytotoxicity; positive regulation of non-membrane spanning protein tyrosine kinase activity; negative regulation of microglial cell migration; positive regulation of gene expression; positive regulation of microglial cell activation; negative regulation of phosphorylation; cellular response to lipopolysaccharide; negative regulation of macrophage colony-stimulating factor signaling pathway; positive regulation of actin cytoskeleton reorganization; negative regulation of macrophage chemotaxis; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	26228
	56792
	ENSG00000035720
	ENSMUSG00000029254
	Q9ULZ2
	Q9JM90
	NM_012108; NM_001317769
	NM_019992; NM_001310639
	NP_001304698; NP_036240
	NP_001297568; NP_064376
	Wikidata
View/Edit Human	View/Edit Mouse

Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.