STAP2

STAP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EL8
Identifiers
Aliases	STAP2, BKS, signal transducing adaptor family member 2
External IDs	OMIM: 607881; MGI: 2147039; HomoloGene: 9798; GeneCards: STAP2; OMA:STAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,342,786 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,312,584 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; mucosa of ileum; ; skin of abdomen; ; skin of leg; ; rectum; ; olfactory zone of nasal mucosa; ; mucosa of sigmoid colon; ; pancreatic ductal cell; ; right lobe of liver; ; minor salivary glands;
	Top expressed in
	intestinal villus; ; jejunum; ; ileum; ; duodenum; ; parotid gland; ; epithelium of small intestine; ; large intestine; ; colon; ; crypt of lieberkuhn of small intestine; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling adaptor activity;
Cellular component	cytoplasm; cytosol; plasma membrane;
Biological process	positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	55620
	106766
	ENSG00000178078
	ENSMUSG00000038781
	Q9UGK3
	Q8R0L1
	NM_001013841; NM_017720
	NM_145934
	NP_001013863; NP_060190
	NP_666046
	Wikidata
View/Edit Human	View/Edit Mouse

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.

This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.