Star related lipid transfer domain containing 3

STARD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EM2, 5I9J
Identifiers
Aliases	STARD3, CAB1, MLN64, es64, StAR related lipid transfer domain containing 3
External IDs	OMIM: 607048; MGI: 1929618; HomoloGene: 38227; GeneCards: STARD3; OMA:STARD3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,664,201 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,271,938 bp
RNA expression pattern
	Top expressed in
	right lung; ; granulocyte; ; tibial nerve; ; right adrenal cortex; ; left adrenal cortex; ; upper lobe of left lung; ; right uterine tube; ; canal of the cervix; ; stromal cell of endometrium; ; anterior pituitary;
	Top expressed in
	granulocyte; ; saccule; ; ectoderm; ; otic vesicle; ; otic placode; ; choroid plexus of fourth ventricle; ; vestibular membrane of cochlear duct; ; yolk sac; ; Ileal epithelium; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipid binding; protein binding; cholesterol binding; cholesterol transfer activity; protein homodimerization activity;
Cellular component	cytoplasm; integral component of membrane; lysosomal membrane; endosome; membrane; late endosome; cytosol; mitochondrion; endoplasmic reticulum membrane; late endosome membrane; organelle membrane contact site; endoplasmic reticulum-endosome membrane contact site;
Biological process	steroid metabolic process; progesterone biosynthetic process; lipid transport; cholesterol metabolic process; mitochondrial transport; lipid metabolism; C21-steroid hormone biosynthetic process; cholesterol transport; vesicle tethering to endoplasmic reticulum; transport;
	Sources:Amigo / QuickGO
Orthologs
	10948
	59045
	ENSG00000131748
	ENSMUSG00000018167
	Q14849
	Q61542
	NM_001165937; NM_001165938; NM_006804
	NM_021547
	NP_001159409; NP_001159410; NP_006795
	NP_067522
	Wikidata
View/Edit Human	View/Edit Mouse

StAR related lipid transfer domain containing 3 (STARD3) is a protein that in humans is encoded by the STARD3 gene. STARD3 also known as metastatic lymph node 64 protein (MLN64) is a late endosomal integral membrane protein involved in cholesterol transport. STARD3 creates membrane contact sites between the endoplasmic reticulum (ER) and late endosomes where it moves cholesterol.