STAT2

STAT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KA4
Identifiers
Aliases	STAT2, ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2, PTORCH3
External IDs	OMIM: 600556; MGI: 103039; HomoloGene: 3952; GeneCards: STAT2; OMA:STAT2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,360,167 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,128,718 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; stromal cell of endometrium; ; monocyte; ; sural nerve; ; pituitary gland; ; anterior pituitary; ; right ovary; ; right lobe of liver; ; tendon of biceps brachii; ; canal of the cervix;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; neural layer of retina; ; epithelium of small intestine; ; cerebellar cortex; ; thymus; ; zygote; ; genital tubercle; ; mucous cell of stomach; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; protein binding; identical protein binding; ubiquitin-like protein ligase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; signal transducer activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	plasma membrane; nucleoplasm; nucleus; cytoplasm; cytosol;
Biological process	receptor signaling pathway via JAK-STAT; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription, DNA-templated; viral process; signal transduction; regulation of protein phosphorylation; defense response to virus; regulation of mitochondrial fission; type I interferon signaling pathway; cytokine-mediated signaling pathway; defense response; regulation of cell population proliferation; response to peptide hormone; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6773
	20847
	ENSG00000170581
	ENSMUSG00000040033
	P52630
	Q9WVL2
NM_005419; NM_198332; NM_001385110; NM_001385111; NM_001385113;
	NM_001385114; NM_001385115
	NM_019963
	NP_005410; NP_938146
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). It functions as a transcription factor downstream of type I interferons. STAT2 sequence identity between mouse and human is only 68%.