STAT3

STAT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AX3
Identifiers
Aliases	STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1
External IDs	OMIM: 102582; MGI: 103038; HomoloGene: 7960; GeneCards: STAT3; OMA:STAT3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,388,568 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,830,366 bp
RNA expression pattern
	Top expressed in
	beta cell; ; pericardium; ; lower lobe of lung; ; lactiferous duct; ; nipple; ; right ventricle; ; upper lobe of lung; ; upper lobe of left lung; ; vena cava; ; epithelium of colon;
	Top expressed in
	right lung lobe; ; ankle; ; granulocyte; ; left lung; ; decidua; ; epithelium of stomach; ; ankle joint; ; stroma of bone marrow; ; skin of external ear; ; tibiofemoral joint;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear receptor activity; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; protein kinase binding; DNA binding; sequence-specific DNA binding; chromatin DNA binding; protein homodimerization activity; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; signal transducer activity; transcription factor binding; CCR5 chemokine receptor binding; glucocorticoid receptor binding;
Cellular component	cytoplasm; mitochondrion; nucleus; plasma membrane; nucleoplasm; RNA polymerase II transcription regulator complex; mitochondrial inner membrane; cytosol; postsynaptic density; Schaffer collateral - CA1 synapse; glutamatergic synapse; transcription regulator complex;
Biological process	negative regulation of glycolytic process; protein import into nucleus; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; response to organic substance; positive regulation of gene silencing by miRNA; radial glial cell differentiation; stem cell population maintenance; cellular response to hormone stimulus; regulation of mitochondrial membrane permeability; growth hormone receptor signaling pathway; miRNA-mediated gene silencing by inhibition of translation; eye photoreceptor cell differentiation; positive regulation of metalloendopeptidase activity; temperature homeostasis; cell population proliferation; response to leptin; response to ethanol; positive regulation of Notch signaling pathway; negative regulation of cell population proliferation; response to cytokine; regulation of transcription, DNA-templated; glucose homeostasis; negative regulation of cell death; transcription, DNA-templated; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of transcription, DNA-templated; negative regulation of hydrogen peroxide biosynthetic process; energy homeostasis; viral process; negative regulation of neuron death; sexual reproduction; phosphorylation; leptin-mediated signaling pathway; cellular response to organic cyclic compound; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; regulation of feeding behavior; nervous system development; positive regulation of ATP biosynthetic process; intracellular receptor signaling pathway; acute-phase response; negative regulation of neuron migration; receptor signaling pathway via JAK-STAT; response to estradiol; response to organic cyclic compound; eating behavior; somatic stem cell population maintenance; regulation of multicellular organism growth; ageing; response to peptide hormone; cellular response to leptin stimulus; regulation of cell cycle; astrocyte differentiation; signal transduction; positive regulation of transcription by RNA polymerase II; growth hormone receptor signaling pathway via JAK-STAT; positive regulation of gene expression; negative regulation of stem cell differentiation; positive regulation of cell population proliferation; mRNA transcription by RNA polymerase II; inflammatory response; positive regulation of erythrocyte differentiation; T-helper 17 cell lineage commitment; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; interleukin-15-mediated signaling pathway; interleukin-7-mediated signaling pathway; positive regulation of angiogenesis; positive regulation of vascular endothelial cell proliferation; cytokine-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-23-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; cellular response to cytokine stimulus; interleukin-9-mediated signaling pathway; modulation of chemical synaptic transmission; postsynapse to nucleus signaling pathway; negative regulation of autophagy; positive regulation of cell migration; positive regulation of NF-kappaB transcription factor activity; defense response; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	6774
	20848
	ENSG00000168610
	ENSMUSG00000004040
	P40763
	P42227
NM_003150; NM_139276; NM_213662; NM_001369512; NM_001369513;
	NM_001369514; NM_001369516; NM_001369517; NM_001369518; NM_001369519; NM_001369520
	NM_011486; NM_213659; NM_213660
NP_003141; NP_644805; NP_998827; NP_001356441; NP_001356442;
	NP_001356443; NP_001356445; NP_001356446; NP_001356447; NP_001356448; NP_001356449
	NP_035616; NP_998824; NP_998825
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family.