STAT5B

STAT5B
Identifiers
Aliases	STAT5B, STAT5, signal transducer and activator of transcription 5B, GHISID2
External IDs	OMIM: 604260; MGI: 103035; HomoloGene: 55718; GeneCards: STAT5B; OMA:STAT5B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,276,707 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,741,550 bp
RNA expression pattern
	Top expressed in
	blood; ; body of uterus; ; left uterine tube; ; right ovary; ; left ovary; ; paraflocculus of cerebellum; ; beta cell; ; frontal pole; ; granulocyte; ; middle frontal gyrus;
	Top expressed in
	medial head of gastrocnemius muscle; ; triceps brachii muscle; ; ankle; ; muscle of thigh; ; temporal muscle; ; vastus lateralis muscle; ; granulocyte; ; thymus; ; sternocleidomastoid muscle; ; seminal vesicula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; glucocorticoid receptor binding; protein dimerization activity; chromatin binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; protein tyrosine kinase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; cytoplasm; nucleus; cytosol;
Biological process	positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; regulation of steroid metabolic process; creatinine metabolic process; T cell differentiation in thymus; female pregnancy; cellular response to hormone stimulus; positive regulation of activated T cell proliferation; progesterone metabolic process; receptor signaling pathway via JAK-STAT; negative regulation of apoptotic process; Peyer's patch development; transcription, DNA-templated; signal transduction; cellular response to growth factor stimulus; natural killer cell differentiation; response to interleukin-4; sex differentiation; valine metabolic process; positive regulation of B cell differentiation; T cell homeostasis; creatine metabolic process; cellular response to epidermal growth factor stimulus; response to estradiol; positive regulation of inflammatory response; regulation of transcription by RNA polymerase II; mast cell migration; positive regulation of mitotic cell cycle; lipid storage; development of secondary female sexual characteristics; fatty acid metabolic process; taurine metabolic process; succinate metabolic process; positive regulation of gamma-delta T cell differentiation; positive regulation of lymphocyte differentiation; regulation of multicellular organism growth; citrate metabolic process; positive regulation of cell population proliferation; oxaloacetate metabolic process; regulation of epithelial cell differentiation; positive regulation of natural killer cell proliferation; development of secondary male sexual characteristics; positive regulation of multicellular organism growth; regulation of transcription, DNA-templated; allantoin metabolic process; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; luteinization; isoleucine metabolic process; negative regulation of erythrocyte differentiation; lactation; response to interleukin-15; regulation of cell adhesion; 2-oxoglutarate metabolic process; response to interleukin-2; growth hormone receptor signaling pathway via JAK-STAT; positive regulation of erythrocyte differentiation; peptidyl-tyrosine phosphorylation; interleukin-7-mediated signaling pathway; interleukin-15-mediated signaling pathway; cytokine-mediated signaling pathway; interleukin-2-mediated signaling pathway; interleukin-9-mediated signaling pathway; defense response; regulation of cell population proliferation; response to peptide hormone;
	Sources:Amigo / QuickGO
Orthologs
	6777
	20851
	ENSG00000173757
	ENSMUSG00000020919
	P51692
	P42232
	NM_012448
	NM_001113563; NM_011489; NM_001362682
	NP_036580
	NP_001107035; NP_035619; NP_001349611
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available.