STEAP1

STEAP1
Identifiers
Aliases	STEAP1, PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDs	OMIM: 604415; MGI: 1917608; HomoloGene: 8256; GeneCards: STEAP1; OMA:STEAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	90,164,829 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	5,799,326 bp
RNA expression pattern
	Top expressed in
	pericardium; ; cartilage tissue; ; prostate; ; tendon of biceps brachii; ; Achilles tendon; ; parietal pleura; ; gonad; ; mucosa of transverse colon; ; abdominal fat; ; gallbladder;
	Top expressed in
	Epithelium of choroid plexus; ; endothelial cell of lymphatic vessel; ; lumbar spinal ganglion; ; epithelium of lens; ; molar; ; hair follicle; ; yolk sac; ; adrenal gland; ; Paneth cell; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ferric-chelate reductase (NADPH) activity; metal ion binding; transporter activity; oxidoreductase activity; cupric reductase activity; channel activity;
Cellular component	endosome membrane; integral component of membrane; cell-cell junction; integral component of plasma membrane; membrane; endosome; plasma membrane;
Biological process	ion transport; copper ion import; iron ion homeostasis; transmembrane transport; iron ion import across cell outer membrane;
	Sources:Amigo / QuickGO
Orthologs
	26872
	70358
	ENSG00000164647
	ENSMUSG00000015652
	Q9UHE8
	Q9CWR7
	NM_012449
	NM_027399
	NP_036581
	NP_081675
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.