STK19

STK19
Identifiers
Aliases	STK19, D6S60, D6S60E, G11, HLA-RP1, RP1, serine/threonine kinase 19
External IDs	OMIM: 604977; MGI: 1860085; HomoloGene: 10449; GeneCards: STK19; OMA:STK19 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,982,821 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,055,921 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; left adrenal cortex; ; right adrenal gland; ; right adrenal cortex; ; right lobe of liver; ; skin of leg; ; anterior pituitary; ; skin of abdomen; ; left ovary; ; right ovary;
	Top expressed in
	bone marrow; ; lip; ; superior frontal gyrus; ; islet of Langerhans; ; duodenum; ; jejunum; ; primary visual cortex; ; proximal tubule; ; adrenal gland; ; granulocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein serine/threonine kinase activity; ATP binding; kinase activity; protein binding;
Cellular component	nucleus; nuclear speck;
Biological process	protein phosphorylation; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	8859
	54402
ENSG00000226257; ENSG00000206342; ENSG00000236250; ENSG00000226033; ENSG00000204344;
	ENSG00000234947
	ENSMUSG00000061207
	P49842
	Q9JHN8
	NM_004197; NM_032454
	NM_019442
	NP_004188; NP_115830
	NP_062315
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase 19 is a protein that in humans is encoded by the STK19 gene and is involved in DNA repair, specifically the Transcription Coupled Nucleotide Excision Repair Pathway (TC-NER).

The name is misleading — although STK19 was initially identified as a serine/threonine kinase, analysis of the crystal structure revealed absence of the kinase domain and it does not seem to possess any kinase activity.

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants.