STK39

STK39
Identifiers
Aliases	STK39, DCHT, PASK, SPAK, serine/threonine kinase 39
External IDs	OMIM: 607648; MGI: 1858416; HomoloGene: 22739; GeneCards: STK39; OMA:STK39 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	168,247,595 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	68,302,612 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Epithelium of choroid plexus; ; Pons; ; parotid gland; ; palpebral conjunctiva; ; pars compacta; ; lateral nuclear group of thalamus; ; pars reticulata; ; inferior ganglion of vagus nerve; ; tibia;
	Top expressed in
	Epithelium of choroid plexus; ; spermatocyte; ; choroid plexus of fourth ventricle; ; spermatid; ; seminiferous tubule; ; tail of embryo; ; salivary gland; ; submandibular gland; ; granulocyte; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity; kinase activity; protein kinase binding;
Cellular component	membrane; basolateral plasma membrane; apical plasma membrane; cytoskeleton; nucleoplasm; extrinsic component of membrane; intracellular membrane-bounded organelle; nucleus; cytoplasm; cytosol;
Biological process	negative regulation of protein phosphorylation; intracellular signal transduction; signal transduction; phosphorylation; positive regulation of potassium ion transport; cellular hypotonic response; regulation of blood pressure; negative regulation of potassium ion transmembrane transporter activity; regulation of inflammatory response; negative regulation of potassium ion transmembrane transport; negative regulation of pancreatic juice secretion; peptidyl-threonine phosphorylation; positive regulation of ion transmembrane transporter activity; maintenance of lens transparency; negative regulation of creatine transmembrane transporter activity; negative regulation of sodium ion transmembrane transporter activity; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process; protein phosphorylation; peptidyl-serine phosphorylation; protein autophosphorylation; ion homeostasis; positive regulation of T cell chemotaxis; chemokine (C-X-C motif) ligand 12 signaling pathway; cellular response to chemokine;
	Sources:Amigo / QuickGO
Orthologs
	27347
	53416
	ENSG00000198648
	ENSMUSG00000027030
	Q9UEW8
	Q9Z1W9
	NM_013233
	NM_016866
	NP_037365
	NP_058562
	Wikidata
View/Edit Human	View/Edit Mouse

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Some studies suggest that this gene might be linked to high blood pressure.