Stathmin

STMN1
Identifiers
Aliases	STMN1, C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, stathmin 1
External IDs	OMIM: 151442; MGI: 96739; HomoloGene: 4063; GeneCards: STMN1; OMA:STMN1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	25,906,991 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	134,201,154 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; C1 segment; ; right frontal lobe; ; right testis; ; left testis; ; right hemisphere of cerebellum; ; gonad; ; prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	ganglionic eminence; ; neural tube; ; Mesencephalon; ; ventricular zone; ; Hypothalamus; ; Cortex of frontal lobe; ; thymus; ; striatum of neuraxis; ; olfactory bulb; ; rhombencephalon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; tubulin binding;
Cellular component	intracellular anatomical structure; cytoplasm; cytoskeleton; microtubule; membrane; cytosol; extracellular exosome; neuron projection;
Biological process	nervous system development; mitotic spindle organization; multicellular organism development; cell differentiation; intracellular signal transduction; response to virus; axonogenesis; neuron projection development; signal transduction; brain development; mitotic cytokinesis; microtubule depolymerization; regulation of microtubule polymerization or depolymerization; negative regulation of microtubule polymerization; negative regulation of Rho protein signal transduction; hepatocyte growth factor receptor signaling pathway; negative regulation of stress fiber assembly; establishment of skin barrier; negative regulation of thrombin-activated receptor signaling pathway; negative regulation of guanyl-nucleotide exchange factor activity; regulation of cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	3925
	16765
	ENSG00000117632
	ENSMUSG00000028832
	P16949
	P54227
	NM_203401; NM_001145454; NM_005563; NM_152497; NM_203399
	NM_019641
	NP_001138926; NP_005554; NP_981944; NP_981946
	NP_062615
	Wikidata
View/Edit Human	View/Edit Mouse

Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene.

Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell cytoskeleton. Changes in the cytoskeleton are important because the cytoskeleton is a scaffold required for many cellular processes, such as cytoplasmic organization, cell division and cell motility. More specifically, stathmin is crucial in regulating the cell cycle. It is found solely in eukaryotes.

Its function as an important regulatory protein of microtubule dynamics has been well-characterized. Eukaryotic microtubules are one of three major components of the cell's cytoskeleton. They are highly dynamic structures that continuously alternate between assembly and disassembly. Stathmin performs an important function in regulating rapid microtubule remodeling of the cytoskeleton in response to the cell's needs. Microtubules are cylindrical polymers of α,β-tubulin. Their assembly is in part determined by the concentration of free tubulin in the cytoplasm.

At low concentrations of free tubulin, the growth rate at the microtubule ends is slowed and results in an increased rate of depolymerization (disassembly).