STS-1 (gene)

UBASH3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CPW, 2E5K
Identifiers
Aliases	UBASH3B, STS-1, STS1, TULA-2, p70, TULA2, ubiquitin associated and SH3 domain containing B
External IDs	OMIM: 609201; MGI: 1920078; HomoloGene: 13152; GeneCards: UBASH3B; OMA:UBASH3B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	122,814,473 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	41,072,993 bp
RNA expression pattern
	Top expressed in
	Pons; ; Cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; cerebellar vermis; ; right hemisphere of cerebellum; ; stromal cell of endometrium; ; decidua; ; blood; ; spleen;
	Top expressed in
	lumbar spinal ganglion; ; trigeminal ganglion; ; Rostral migratory stream; ; zygote; ; supraoptic nucleus; ; otolith organ; ; utricle; ; secondary oocyte; ; cerebellar vermis; ; lobe of cerebellum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; protein binding; phosphoprotein phosphatase activity; hydrolase activity; identical protein binding; phosphoprotein binding; ubiquitin protein ligase binding; phosphatase activity;
Cellular component	cytoplasm; nucleus;
Biological process	regulation of release of sequestered calcium ion into cytosol; negative regulation of signal transduction; peptidyl-tyrosine dephosphorylation; negative regulation of platelet aggregation; regulation of osteoclast differentiation; negative regulation of protein kinase activity; negative regulation of osteoclast differentiation; negative regulation of bone resorption; platelet activation; collagen-activated tyrosine kinase receptor signaling pathway; collagen-activated signaling pathway; platelet aggregation; regulation of protein binding;
	Sources:Amigo / QuickGO
Orthologs
	84959
	72828
	ENSG00000154127
	ENSMUSG00000032020
	Q8TF42
	Q8BGG7
	NM_032873; NM_001363365
	NM_176860; NM_001357412
	NP_116262; NP_001350294
	NP_789830; NP_001344341
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.

This gene encodes a protein that contains a ubiquitin associated protein domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.