STUB1

STUB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KBQ
Identifiers
Aliases	STUB1, CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1, STIP1 homology and U-box containing protein 1, SCA48
External IDs	OMIM: 607207; MGI: 1891731; HomoloGene: 4281; GeneCards: STUB1; OMA:STUB1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	682,870 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,052,378 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; postcentral gyrus; ; pars compacta; ; external globus pallidus; ; pars reticulata; ; spinal ganglia; ; superior vestibular nucleus; ; ventral tegmental area; ; parotid gland; ; Pons;
	Top expressed in
	neural tube; ; lens; ; bone marrow; ; islet of Langerhans; ; Mesencephalon; ; adrenal gland; ; rhombencephalon; ; striatum of neuraxis; ; Hypothalamus; ; urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	Hsp90 protein binding; protein-macromolecule adaptor activity; protein homodimerization activity; misfolded protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; kinase binding; protein binding; enzyme binding; TPR domain binding; G protein-coupled receptor binding; ubiquitin protein ligase binding; transferase activity; Hsp70 protein binding; SMAD binding; heat shock protein binding; tau protein binding; chaperone binding;
Cellular component	cytoplasm; ubiquitin ligase complex; nucleoplasm; Z discdkac; endoplasmic reticulum; nuclear inclusion body; extracellular exosome; ubiquitin conjugating enzyme complex; nucleus; cytosol; chaperone complex;
Biological process	positive regulation of chaperone-mediated protein complex assembly; regulation of protein stability; ubiquitin-dependent protein catabolic process; regulation of glucocorticoid metabolic process; protein K63-linked ubiquitination; protein maturation; protein polyubiquitination; protein quality control for misfolded or incompletely synthesized proteins; negative regulation of protein binding; ubiquitin-dependent SMAD protein catabolic process; cellular response to DNA damage stimulus; endoplasmic reticulum unfolded protein response; positive regulation of ubiquitin-protein transferase activity; protein ubiquitination; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; cellular response to misfolded protein; ERBB2 signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; ubiquitin-dependent ERAD pathway; response to ischemia; cellular response to heat; chaperone-mediated autophagy; cellular response to hypoxia;
	Sources:Amigo / QuickGO
Orthologs
	10273
	56424
	ENSG00000103266
	ENSMUSG00000039615
	Q9UNE7
	Q9WUD1
	NM_005861; NM_001293197
	NM_019719
	NP_001280126; NP_005852
	NP_062693
	Wikidata
View/Edit Human	View/Edit Mouse

STUB1 (STIP1 homology and U-Box containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein).