SUB1

SUB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PCF, 2C62, 2PHE, 4USG
Identifiers
Aliases	SUB1, P15, PC4, p14, SUB1 homolog, transcriptional regulator, SUB1 regulator of transcription
External IDs	OMIM: 600503; MGI: 104811; HomoloGene: 38218; GeneCards: SUB1; OMA:SUB1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	32,604,079 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	11,997,069 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; lactiferous duct; ; epithelium of colon; ; ganglionic eminence; ; gingival epithelium; ; parotid gland; ; bone marrow cells; ; germinal epithelium; ; endometrium; ; ventricular zone;
	Top expressed in
	genital tubercle; ; tail of embryo; ; yolk sac; ; abdominal wall; ; primitive streak; ; neural tube; ; gastrula; ; medial ganglionic eminence; ; migratory enteric neural crest cell; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	single-stranded DNA binding; DNA binding; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; RNA binding; identical protein binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleolus; extracellular exosome; transcription regulator complex; nucleus;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription by RNA polymerase II; SMAD protein signal transduction; transcription, DNA-templated; positive regulation of transcription initiation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	10923
	20024
	ENSG00000113387
	ENSMUSG00000022205
	P53999
	P11031
	NM_006713
	NM_011294
	NP_006704
	NP_035424
	Wikidata
View/Edit Human	View/Edit Mouse

Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene. The human SUB1 gene is named after an orthologous gene in yeast.

SUB1 is induced by oxidative stress, and is involved in coordinating cellular responses to DNA strand breaks that arise after oxidative stress.Yu L, Ma H, Ji X, Volkert MR (January 2016). "The Sub1 nuclear protein protects DNA from oxidative damage". Molecular and Cellular Biochemistry. 412 (1–2): 165–171. doi:10.1007/s11010-015-2621-x. PMC 5064834. PMID 26708217. Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease.Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, et al. (July 2019). "Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders". Scientific Reports. 9 (1): 10919. doi:10.1038/s41598-019-47227-z. PMC 6662836. PMID 31358782. Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks.