SUFU

SUFU
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH
Identifiers
Aliases	SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS32
External IDs	OMIM: 607035; MGI: 1345643; HomoloGene: 9262; GeneCards: SUFU; OMA:SUFU - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,633,535 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,477,243 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; nipple; ; body of tongue; ; vein; ; stromal cell of endometrium; ; synovial membrane; ; mucosa of pharynx; ; saphenous vein; ; trigeminal ganglion; ; internal globus pallidus;
	Top expressed in
	otic vesicle; ; seminiferous tubule; ; saccule; ; otic placode; ; secondary oocyte; ; zygote; ; primary oocyte; ; spermatogonium; ; epiblast; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; transcription corepressor activity; transcription factor binding; signal transducer activity; protein binding; protein kinase binding;
Cellular component	cytosol; cilium; ciliary base; ciliary tip; nucleus; cytoplasm;
Biological process	skeletal system development; regulation of transcription, DNA-templated; ventricular septum development; smoothened signaling pathway involved in ventral spinal cord interneuron specification; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; spinal cord dorsal/ventral patterning; negative regulation of transcription by RNA polymerase II; coronary vasculature development; negative regulation of DNA-binding transcription factor activity; negative regulation of osteoblast differentiation; proteolysis; heart looping; aorta development; neural tube closure; determination of left/right symmetry; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; negative regulation of ubiquitin-dependent protein catabolic process; signal transduction; skin development; multicellular organism development; cytoplasmic sequestering of transcription factor; negative regulation of protein import into nucleus; negative regulation of smoothened signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	51684
	24069
	ENSG00000107882
	ENSMUSG00000025231
	Q9UMX1
	Q9Z0P7
	NM_001178133; NM_016169
	NM_001025391; NM_015752
	NP_001171604; NP_057253
	NP_001020562; NP_056567
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is crucial in embryonic development. There are several homologues of Sufu, found in a wide variety of organisms.