SURF4

SURF4
Identifiers
Aliases	SURF4, ERV29, surfeit 4
External IDs	OMIM: 185660; MGI: 98445; HomoloGene: 6052; GeneCards: SURF4; OMA:SURF4 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,376,166 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; stromal cell of endometrium; ; duodenum; ; body of pancreas; ; placenta; ; right lobe of liver; ; gallbladder; ; smooth muscle tissue; ; left adrenal gland; ; left adrenal cortex;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum; membrane; endoplasmic reticulum-Golgi intermediate compartment; transport vesicle; endoplasmic reticulum membrane; Golgi membrane; plasma membrane; azurophil granule membrane; cytosol;
Biological process	early endosome to Golgi transport; positive regulation of organelle organization; protein exit from endoplasmic reticulum; Golgi organization; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	6836
	20932
	ENSG00000148248; ENSG00000280951
	n/a
	O15260
	Q64310
NM_001280788; NM_001280789; NM_001280790; NM_001280791; NM_001280792;
	NM_001280793; NM_033161
	NM_011512
NP_001267717; NP_001267718; NP_001267719; NP_001267720; NP_001267721;
	NP_001267722; NP_149351
	NP_035642
	Wikidata
View/Edit Human	View/Edit Mouse

Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies. Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9. It recognizes cargo proteins via a three-amino-acid sequence near the N-termini. The related protein in yeast is called Erv29p.

This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.

Eliminating Surf4 in the liver reduces the amount of lipid in the plasma and prevents atherosclerosis in mice.