SYNCRIP

SYNCRIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DGU, 2MXT, 2NBB
Identifiers
Aliases	SYNCRIP, GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q, synaptotagmin binding cytoplasmic RNA interacting protein
External IDs	OMIM: 616686; MGI: 1891690; HomoloGene: 4648; GeneCards: SYNCRIP; OMA:SYNCRIP - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	85,644,063 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	88,364,627 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; amniotic fluid; ; skin of thigh; ; skin of hip; ; tendon of biceps brachii; ; sperm; ; stromal cell of endometrium; ; secondary oocyte; ; tail of epididymis;
	Top expressed in
	tail of embryo; ; ventricular zone; ; aortic valve; ; ascending aorta; ; mandibular prominence; ; hand; ; maxillary prominence; ; epiblast; ; abdominal wall; ; ganglionic eminence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	poly(A) binding; protein binding; nucleic acid binding; RNA binding; mRNA binding; mRNA 5'-UTR binding;
Cellular component	CRD-mediated mRNA stability complex; cytoplasm; catalytic step 2 spliceosome; histone pre-mRNA 3'end processing complex; intracellular membrane-bounded organelle; nucleoplasm; endoplasmic reticulum; GAIT complex; spliceosomal complex; nucleus; membrane; ribonucleoprotein complex;
Biological process	CRD-mediated mRNA stabilization; mRNA splicing, via spliceosome; RNA processing; negative regulation of translation; mRNA processing; osteoblast differentiation; RNA splicing; cellular response to interferon-gamma; viral process; regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	10492
	56403
	ENSG00000135316
	ENSMUSG00000032423
	O60506
	Q7TMK9
NM_001159673; NM_001159674; NM_001159675; NM_001159676; NM_001159677;
	NM_001253771; NM_006372
	NM_001284328; NM_019666; NM_019796; NM_001311113
NP_001153145; NP_001153146; NP_001153147; NP_001153148; NP_001153149;
	NP_001240700; NP_006363
	NP_001271257; NP_001298042; NP_062640; NP_062770
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP), also known as heterogeneous nuclear ribonucleoprotein (hnRNP) Q or NS1-associated protein-1 (NSAP-1), is a protein that in humans is encoded by the SYNCRIP gene. As the name implies, SYNCRIP is localized predominantly in the cytoplasm. It is evolutionarily conserved across eukaryotes and participates in several cellular and disease pathways, especially in neuronal and muscular development. In humans, there are three isoforms, all of which are associated in vitro with pre-mRNAs, mRNA splicing intermediates, and mature mRNA-protein complexes, including mRNA turnover.