SYNGR1

SYNGR1
Identifiers
Aliases	SYNGR1, synaptogyrin 1
External IDs	OMIM: 603925; MGI: 1328323; HomoloGene: 3456; GeneCards: SYNGR1; OMA:SYNGR1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,385,575 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	80,003,702 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; frontal pole; ; right frontal lobe; ; lateral nuclear group of thalamus; ; cerebellar vermis; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; cerebellar cortex; ; prefrontal cortex; ; subiculum; ; medial dorsal nucleus; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; medial geniculate nucleus; ; cerebellar vermis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	melanosome; integral component of membrane; cell junction; neuromuscular junction; synapse; synaptic vesicle membrane; membrane; synaptic vesicle; plasma membrane; azurophil granule membrane; cytoplasmic vesicle; integral component of synaptic vesicle membrane;
Biological process	regulation of short-term neuronal synaptic plasticity; protein targeting; regulation of long-term neuronal synaptic plasticity; neutrophil degranulation; cellular response to leukemia inhibitory factor; regulated exocytosis; synaptic vesicle membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	9145
	20972
	ENSG00000100321
	ENSMUSG00000022415
	O43759
	O55100
	NM_145738; NM_004711; NM_145731
	NM_009303; NM_207708
	NP_004702; NP_663783; NP_663791
	NP_033329; NP_997591
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptogyrin-1 is a protein that in humans is encoded by the SYNGR1 gene.

This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified.