Synemin

SYNM
Identifiers
Aliases	SYNM, DMN, SYN, synemin
External IDs	OMIM: 606087; MGI: 2661187; HomoloGene: 9081; GeneCards: SYNM; OMA:SYNM - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	99,135,593 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	67,409,490 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; saphenous vein; ; Skeletal muscle tissue of rectus abdominis; ; glutes; ; vastus lateralis muscle; ; tail of epididymis; ; Skeletal muscle tissue of biceps brachii; ; optic nerve; ; right ventricle; ; deltoid muscle;
	Top expressed in
	triceps brachii muscle; ; knee joint; ; medial head of gastrocnemius muscle; ; vastus lateralis muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; muscle of thigh; ; digastric muscle; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	vinculin binding; protein binding; structural molecule activity; intermediate filament binding; structural constituent of cytoskeleton; structural constituent of muscle;
Cellular component	cytoplasm; cell junction; costamere; membrane; cytoskeleton; intermediate filament; adherens junction; neurofilament cytoskeleton; sarcolemma;
Biological process	intermediate filament cytoskeleton organization; fast-twitch skeletal muscle fiber contraction;
	Sources:Amigo / QuickGO
Orthologs
	23336
	233335
	ENSG00000182253
	ENSMUSG00000030554
	O15061
	Q70IV5
	NM_145728; NM_015286
	NM_183312; NM_201639; NM_207663
	NP_056101; NP_663780
	NP_899135; NP_964001; NP_997546
	Wikidata
View/Edit Human	View/Edit Mouse

Synemin, also known as desmuslin, is a protein that in humans is encoded by the SYNM gene. Synemin is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle.