SYT4

SYT4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UGK
Identifiers
Aliases	SYT4, HsT1192, synaptotagmin 4
External IDs	OMIM: 600103; MGI: 101759; HomoloGene: 7559; GeneCards: SYT4; OMA:SYT4 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	43,277,535 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	31,580,459 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; endothelial cell; ; cerebellar hemisphere; ; Brodmann area 23; ; right hemisphere of cerebellum; ; Brodmann area 46; ; middle temporal gyrus; ; superior frontal gyrus; ; superior vestibular nucleus; ; islet of Langerhans;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; ventral tegmental area; ; pineal gland; ; dorsomedial hypothalamic nucleus; ; habenula; ; anterior amygdaloid area; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; clathrin binding; phosphatidylserine binding; metal ion binding; protein binding; SNARE binding; syntaxin-1 binding; syntaxin binding; syntaxin-3 binding; protein homodimerization activity; protein heterodimerization activity; calcium-dependent phospholipid binding;
Cellular component	integral component of membrane; intracellular membrane-bounded organelle; membrane; synapse; synaptic vesicle membrane; cell junction; perinuclear region of cytoplasm; neuron projection; dense core granule; cytoplasmic vesicle; dendrite; Golgi apparatus; vesicle; axon; plasma membrane; synaptic vesicle; integral component of Golgi membrane; integral component of synaptic vesicle membrane; secretory granule membrane; dense core granule membrane; somatodendritic compartment; soma; neuron projection terminus; exocytic vesicle; astrocyte projection; microvesicle; glutamatergic synapse; integral component of neuronal dense core vesicle membrane;
Biological process	cell differentiation; brain development; positive regulation of dendrite extension; negative regulation of vesicle fusion; neurotransmitter secretion; exocytosis; vesicle fusion; calcium ion-regulated exocytosis of neurotransmitter; memory; positive regulation of glutamate secretion; regulation of dopamine secretion; regulation of endocytosis; regulation of vesicle fusion; negative regulation of catecholamine secretion; positive regulation of calcium ion-dependent exocytosis; negative regulation of neurotransmitter secretion; negative regulation of short-term neuronal synaptic plasticity; vesicle fusion with vesicle; secretory granule maturation; negative regulation of protein secretion; negative regulation of retrograde trans-synaptic signaling by neuropeptide; regulation of calcium ion-dependent exocytosis; negative regulation of calcium ion-dependent exocytosis; trans-synaptic signaling by BDNF, modulating synaptic transmission; vesicle-mediated transport; calcium-ion regulated exocytosis; cellular response to calcium ion; regulation of presynaptic dense core granule exocytosis; negative regulation of dense core granule exocytosis; positive regulation of dense core granule exocytosis; negative regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	6860
	20983
	ENSG00000132872
	ENSMUSG00000024261
	Q9H2B2
	P40749
	NM_020783
	NM_009308
	NP_065834
	NP_033334
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.