SYVN1

SYVN1
Identifiers
Aliases	SYVN1, DER3, HRD1, synoviolin 1
External IDs	OMIM: 608046; MGI: 1921376; HomoloGene: 32700; GeneCards: SYVN1; OMA:SYVN1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,134,532 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,103,742 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; body of pancreas; ; right lobe of liver; ; bone marrow cells; ; appendix; ; stromal cell of endometrium; ; islet of Langerhans; ; right lobe of thyroid gland; ; lymph node; ; left lobe of thyroid gland;
	Top expressed in
	mesenteric lymph nodes; ; lacrimal gland; ; salivary gland; ; decidua; ; left lobe of liver; ; islet of Langerhans; ; molar; ; spleen; ; seminal vesicula; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	chaperone binding; unfolded protein binding; ATPase binding; metal ion binding; protein binding; ubiquitin-specific protease binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; nucleoplasm; smooth endoplasmic reticulum; integral component of endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; Derlin-1 retrotranslocation complex; Hrd1p ubiquitin ligase complex; Hrd1p ubiquitin ligase ERAD-L complex; membrane; endoplasmic reticulum;
Biological process	protein stabilization; protein K48-linked ubiquitination; retrograde protein transport, ER to cytosol; IRE1-mediated unfolded protein response; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein N-linked glycosylation via asparagine; endoplasmic reticulum mannose trimming; ERAD pathway; endoplasmic reticulum unfolded protein response; ubiquitin-dependent ERAD pathway; protein ubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	84447
	74126
	ENSG00000162298
	ENSMUSG00000024807
	Q86TM6
	Q9DBY1
	NM_032431; NM_172230
	NM_001164709; NM_028769
	NP_115807; NP_757385
	NP_001158181; NP_083045
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase synoviolin is an enzyme that in humans is encoded by the SYVN1 gene.