Santa Fe, Colón
| Santa Fé Guadalupe Colon | |
|---|---|
| Municipality | |
| Nickname: Giriga | |
| Coordinates: 15°55′N 86°2′W / 15.917°N 86.033°W | |
| Country | Honduras | 
| Department | Colón | 
| Area | |
|  • Total | 196 km2 (76 sq mi) | 
| Population  (2016) | |
|  • Total | 5,390 | 
Santa Fe is a municipality in the Honduran department of Colón.
Notable people from Santa Fe include Miriam Miranda, a Honduran human rights activist who advocates for the land rights of the Garífuna people.