Sarcospan

SSPN
Identifiers
Aliases	SSPN, DAGA5, KRAG, NSPN, SPN1, SPN2, sarcospan
External IDs	OMIM: 601599; MGI: 1353511; HomoloGene: 3727; GeneCards: SSPN; OMA:SSPN - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	26,299,290 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	145,910,949 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; urethra; ; saphenous vein; ; trigeminal ganglion; ; Achilles tendon; ; vena cava; ; spinal ganglia; ; tibia;
	Top expressed in
	myocardium of ventricle; ; cardiac muscles; ; cardiac muscle tissue of left ventricle; ; thoracic diaphragm; ; digastric muscle; ; interventricular septum; ; triceps brachii muscle; ; vastus lateralis muscle; ; ankle; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Orthologs
	8082
	16651
	ENSG00000123096
	ENSMUSG00000030255
	Q14714
	Q62147
	NM_001135823; NM_005086
	NM_010656; NM_001310837
	NP_001129295; NP_005077
	NP_001297766; NP_034786
	Wikidata
View/Edit Human	View/Edit Mouse

Sarcospan is a protein that in humans is encoded by the SSPN gene.

Originally identified as Kirsten ras associated gene (KRAG), sarcospan is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells, where it is most abundant. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly. Loss of SSPN expression occurs in patients with Duchenne muscular dystrophy. Dystrophin is required for proper localization of SSPN. SSPN is also an essential regulator of Akt signaling pathways. Without SSPN, Akt signaling pathways will be hindered and muscle regeneration will not occur.