List of second overall NFL draft picks

This is a list of second overall National Football League (NFL) draft picks. The NFL draft is an annual sports draft in which National Football League teams select newly eligible players for their rosters. Thirteen players selected second overall have been inducted into the Pro Football Hall of Fame: Sid Luckman (1939), George McAfee (1940), Les Richter (1952), Bob Brown (1964), Tom Mack (1966), Randy White (1975), Tony Dorsett (1977), Lawrence Taylor (1981), Eric Dickerson (1983), Marshall Faulk (1994), Calvin Johnson (2007), Tony Boselli (1995), and Julius Peppers (2002). In 2012, Sports Illustrated chose Taylor as the best player selected second overall.

Eight Heisman Trophy winners have been selected at the spot: Glenn Davis (1946), Billy Vessels (1952), John David Crow (1957), Reggie Bush (2006), Robert Griffin III (2012), Marcus Mariota (2014), Jayden Daniels (2024), and Travis Hunter (2025). Notable draft busts selected include Lam Jones (1980), Tony Mandarich (1989), Blair Thomas (1990), Ryan Leaf (1998), Charles Rogers (2003), Jason Smith (2009), Mitchell Trubisky (2017), and Zach Wilson (2021). The Cleveland / St. Louis / Los Angeles Rams have had nine selections at the spot, the most in the NFL.