Sekihoku Main Line (石北本線, Sekihoku-honsen) is a railway line in Hokkaido, Japan, operated by Hokkaido Railway Company (JR Hokkaido) between Shin-Asahikawa in Asahikawa and Abashiri Station in Abashiri. The name comes from the first Kanji characters of Ishikari Province (石狩国) and Kitami Province (北見国), names of 19th century provinces along the line.
On 19 November 2016, JR Hokkaido's President announced plans to rationalise the network by up to 1,237 km (769 mi), or ~50% of the current network, including the proposed conversion to Third Sector operation of the Sekihoku Main Line, but if local governments are not agreeable, the line will face closure.