Sirtuin 6

SIRT6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3K35, 3PKI, 3PKJ, 3ZG6
Identifiers
Aliases	SIRT6, SIR2L6, sirtuin 6
External IDs	OMIM: 606211; MGI: 1354161; HomoloGene: 6924; GeneCards: SIRT6; OMA:SIRT6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,182,566 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,463,631 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; granulocyte; ; tendon of biceps brachii; ; anterior pituitary; ; right hemisphere of cerebellum; ; body of pancreas; ; apex of heart; ; spleen; ; left adrenal cortex; ; right adrenal gland;
	Top expressed in
	morula; ; neural tube; ; zygote; ; ventricular zone; ; yolk sac; ; blastocyst; ; granulocyte; ; lip; ; ascending aorta; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity; transcription corepressor activity; protein deacetylase activity; zinc ion binding; chromatin binding; metal ion binding; protein binding; NAD+ ADP-ribosyltransferase activity; hydrolase activity; NAD-dependent protein deacetylase activity; NAD+ binding; NAD+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); histone deacetylase activity;
Cellular component	cytoplasm; nucleolus; nucleoplasm; nucleus;
Biological process	negative regulation of glycolytic process; glucose homeostasis; regulation of double-strand break repair via homologous recombination; positive regulation of fibroblast proliferation; protein deacetylation; negative regulation of glucose import; response to nutrient levels; protein destabilization; post-embryonic cardiac muscle cell growth involved in heart morphogenesis; negative regulation of transcription, DNA-templated; positive regulation of stem cell proliferation; base-excision repair; negative regulation of cell population proliferation; histone deacetylation; histone H3-K9 modification; histone H3-K9 deacetylation; protein ADP-ribosylation; positive regulation of telomere maintenance; positive regulation of chondrocyte proliferation; positive regulation of blood vessel branching; positive regulation of vascular endothelial cell proliferation; positive regulation of cold-induced thermogenesis; negative regulation of transcription by RNA polymerase II; histone H3 deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	51548
	50721
	ENSG00000077463
	ENSMUSG00000034748
	Q8N6T7
	P59941
NM_001193285; NM_016539; NM_001321058; NM_001321059; NM_001321060;
	NM_001321061; NM_001321062; NM_001321063; NM_001321064
	NM_001163430; NM_181586; NM_001378944; NM_001378945
NP_001180214; NP_001307987; NP_001307988; NP_001307989; NP_001307990;
	NP_001307991; NP_001307992; NP_001307993; NP_057623
	NP_001156902; NP_853617; NP_001365873; NP_001365874
	Wikidata
View/Edit Human	View/Edit Mouse

Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. SIRT6 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.