Sjögren's disease

Sjögren's disease
Other namesSjögren's syndrome, sicca syndrome
Image with a microscope of focal lymphoid infiltration in the minor salivary gland associated with Sjögren's disease
Pronunciation
  • UK: /ˈʃɜːɡrɛn/, US: /ˈʃɡrɛn/
    Swedish: [ˈɧø̂ːɡreːn]
SpecialtyImmunology, rheumatology 
SymptomsDry mouth, dry eyes, other areas of dryness
ComplicationsLymphoma
Usual onsetMiddle age
DurationLong term
CausesAutoimmune disease (unknown cause)
Diagnostic methodTissue biopsy, blood tests
Differential diagnosisMedication side effect, anxiety, sarcoidosis, amyloidosis
TreatmentArtificial tears, medications to reduce inflammation, surgery
PrognosisNormal life expectancy
Frequency~0.7%

Sjögren's disease (SjD), previously known as Sjögren syndrome or Sjögren's syndrome (SjS, SS), is a long-term autoimmune disease that primarily affects the body's exocrine glands, particularly the lacrimal and salivary glands. Common symptoms include dry mouth, dry eyes and often seriously affect other organ systems, such as the lungs, kidneys, and nervous system.