Solifenacin

Solifenacin
Clinical data
Trade names	Vesicare, Vesicare LS
Other names	YM905
AHFS/Drugs.com	Monograph
MedlinePlus	a605019
License data	US DailyMed: Solifenacin;
Pregnancy; category	AU: B3;
Routes of; administration	By mouth
ATC code	G04BD08 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	90%
Protein binding	98%
Metabolism	CYP3A4
Metabolites	Glucuronide, N-oxide, others
Elimination half-life	45 to 68 hours
Excretion	Kidney (69.2%) and fecal (22.5%)
Identifiers
	IUPAC name (3R)-1-Azabicyclo[2 2 2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate;
CAS Number	242478-37-1 ;
PubChem CID	154059;
IUPHAR/BPS	7483;
DrugBank	DB01591 ;
ChemSpider	135771 ;
UNII	A8910SQJ1U;
KEGG	DG00481 ;
ChEMBL	ChEMBL1734 ;
CompTox Dashboard (EPA)	DTXSID3048289 ;
Chemical and physical data
Formula	C23H26N2O2
Molar mass	362.473 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5;
	InChI InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1 ; Key:FBOUYBDGKBSUES-VXKWHMMOSA-N ;
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Solifenacin, sold as the brand name Vesicare among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). It may help with incontinence, urinary frequency, and urinary urgency.

Benefits appear similar to other medications in the class. It is taken by mouth.

Common side effects include dry mouth, constipation, and urinary tract infection. Severe side effects may include urinary retention, QT prolongation, hallucinations, glaucoma, and anaphylaxis. It is unclear if use is safe during pregnancy. It is of the antimuscarinic class and works by decreasing bladder contractions.

Solifenacin was approved for medical use in the United States in 2004. In 2022, it was the 210th most commonly prescribed medication in the United States, with more than 1 million prescriptions.