Sorting nexin
| PX domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. | |||||||||
| Identifiers | |||||||||
| Symbol | PX | ||||||||
| Pfam | PF00787 | ||||||||
| InterPro | IPR001683 | ||||||||
| SMART | PX | ||||||||
| PROSITE | PDOC50195 | ||||||||
| SCOP2 | 1h6h / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 57 | ||||||||
| OPM protein | 4on3 | ||||||||
| |||||||||
| Sorting nexin, N-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Sorting_nexin | ||||||||
| Pfam | PF03700 | ||||||||
| InterPro | IPR005329 | ||||||||
| |||||||||
| Vps5 C terminal like (BAR domain) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Vps5 | ||||||||
| Pfam | PF09325 | ||||||||
| InterPro | IPR015404 | ||||||||
| |||||||||
| Sorting nexin, C terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Nexin_C | ||||||||
| Pfam | PF08628 | ||||||||
| InterPro | IPR013937 | ||||||||
| |||||||||
| WASP-binding domain of Sorting nexin protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BAR3-WASP | ||||||||
| Pfam | PF10456 | ||||||||
| |||||||||
Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.