Spruce Run (Little Fishing Creek tributary)

Spruce Run
Spruce Run at Pennsylvania Route 254, looking upstream
Physical characteristics
Source 
  locationvalley in northern Madison Township, Columbia County, Pennsylvania
  elevation1,220 ft (370 m)
Mouth 
  location
Little Fishing Creek in Madison Township, Columbia County, Pennsylvania
  coordinates
41°04′57″N 76°31′07″W / 41.0826°N 76.5186°W / 41.0826; -76.5186
  elevation
564 ft (172 m)
Length6.9 mi (11.1 km)
Basin size9.80 sq mi (25.4 km2)
Basin features
ProgressionLittle Fishing Creek → Fishing CreekSusquehanna RiverChesapeake Bay

Spruce Run is a tributary of Little Fishing Creek in Columbia County, Pennsylvania, in the United States. It is approximately 6.9 miles (11.1 km) long and flows through Madison Township. The watershed of the stream has an area of 9.80 square miles (25.4 km2). Several people settled on the stream in the 1780s and 1790s. Two bridges were built over it in the 20th century.

Spruce Run is designated as a "Locally Significant Area" in the Columbia County Natural Areas Inventory. More than 80 species of woodland herbs and numerous trees, mammals, and birds inhabit the area near the stream. The Pennsylvania State Game Lands are also in the watershed.