Streptolysin
| Streptolysin O | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | slo | ||||||
| UniProt | P0C0I3 | ||||||
| |||||||
| Streptolysin S | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | sagA | ||||||
| UniProt | Q1J7I0 | ||||||
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Streptolysins are two homogenous exotoxins from Streptococcus pyogenes. Types include streptolysin O (SLO; slo), which is oxygen-labile, and streptolysin S (SLS; sagA), which is oxygen-stable.
SLO is part of the thiol-activated cytolysin family. It is hemolytically active only in a reversibly reduced state. It is antigenic, so its antibody antistreptolysin O can be detected in an antistreptolysin O titre.
SLS is stable in the presence of oxygen. It is not antigenic due to its small size. It is sometimes considered a bacteriocin due to similarities in the synthesis pathway.