Succinyl coenzyme A synthetase
| Succinate—CoA ligase (GDP-forming) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Pig GTP-specific succinyl-CoA synthetase with GTP. PDB 2fp4 | |||||||||
| Identifiers | |||||||||
| EC no. | 6.2.1.4 | ||||||||
| CAS no. | 9014-36-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Succinate—CoA ligase (ADP-forming) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Succinyl-COA synthetase from Escherichia coli. PDB 2scu | |||||||||
| Identifiers | |||||||||
| EC no. | 6.2.1.5 | ||||||||
| CAS no. | 9080-33-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Succinyl coenzyme A synthetase (SCS, also known as succinyl-CoA synthetase or succinate thiokinase or succinate-CoA ligase) is an enzyme that catalyzes the reversible reaction of succinyl-CoA to succinate. The enzyme facilitates the coupling of this reaction to the formation of a nucleoside triphosphate molecule (either GTP or ATP) from an inorganic phosphate molecule and a nucleoside diphosphate molecule (either GDP or ADP). It plays a key role as one of the catalysts involved in the citric acid cycle, a central pathway in cellular metabolism, and it is located within the mitochondrial matrix of a cell.