Supramolecular catalysis

Supramolecular catalysis refers to an application of supramolecular chemistry, especially molecular recognition and guest binding, toward catalysis. This field was originally inspired by enzymatic system which, unlike classical organic chemistry reactions, utilizes non-covalent interactions such as hydrogen bonding, cation-pi interaction, and hydrophobic forces to dramatically accelerate rate of reaction and/or allow highly selective reactions to occur. Because enzymes are structurally complex and difficult to modify, supramolecular catalysts offer a simpler model for studying factors involved in catalytic efficiency of the enzyme.^: 1 Another goal that motivates this field is the development of efficient and practical catalysts that may or may not have an enzyme equivalent in nature.

A related field of study is asymmetric catalysis which requires molecular recognition to differentiate enantiomeric starting materials. It could be categorized as an area of supramolecular catalysis, but supramolecular catalysis however does not necessarily involve asymmetric reactions.