TAAR8

TAAR8
Identifiers
Aliases	TAAR8, GPR102, TA5, TAR5, TRAR5, TaR-5, TaR-8, trace amine associated receptor 8
External IDs	OMIM: 606927; MGI: 2685995; HomoloGene: 77586; GeneCards: TAAR8; OMA:TAAR8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,553,721 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	23,968,192 bp
RNA expression pattern
	Top expressed in
	pancreas; ; female reproductive system; ; organ system; ; material anatomical entity; ; kidney; ; renal cortex; ; vagina; ; islet of Langerhans; ; tibial nerve;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	trace-amine receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	83551
	382348
	ENSG00000146385
	ENSMUSG00000100186
	Q969N4
	Q5QD06
	NM_053278
	NM_001010837
	NP_444508
	NP_001010837
	Wikidata
View/Edit Human	View/Edit Mouse

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene. In humans, TAAR8 is the only trace amine-associated receptor that is known to be G_i/o-coupled.

In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors.

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins, supplied by OMIM