TAB1

TAB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L53, 4O91, 5DIY, 5JGA, 5JGD
Identifiers
Aliases	TAB1, 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
External IDs	OMIM: 602615; MGI: 1913763; HomoloGene: 4461; GeneCards: TAB1; OMA:TAB1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,437,060 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	80,045,908 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; lateral nuclear group of thalamus; ; ventricular zone; ; right hemisphere of cerebellum; ; sural nerve; ; apex of heart; ; Skeletal muscle tissue of rectus abdominis; ; right frontal lobe; ; subthalamic nucleus; ; right ventricle;
	Top expressed in
	otic vesicle; ; ventricular zone; ; neural layer of retina; ; internal carotid artery; ; external carotid artery; ; granulocyte; ; saccule; ; muscle of thigh; ; right kidney; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; catalytic activity; kinase activator activity; enzyme activator activity; protein-containing complex binding; mitogen-activated protein kinase p38 binding; protein kinase activator activity;
Cellular component	endosome membrane; cytosol; nuclear speck; protein-containing complex; nucleus;
Biological process	cardiac septum development; lung development; protein dephosphorylation; heart morphogenesis; stimulatory C-type lectin receptor signaling pathway; in utero embryonic development; MyD88-dependent toll-like receptor signaling pathway; coronary vasculature development; Fc-epsilon receptor signaling pathway; JNK cascade; aorta development; positive regulation of NF-kappaB transcription factor activity; I-kappaB kinase/NF-kappaB signaling; transforming growth factor beta receptor signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of MAP kinase activity; protein deubiquitination; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10454
	66513
	ENSG00000100324
	ENSMUSG00000022414
	Q15750
	Q8CF89
	NM_153497; NM_006116
	NM_025609
	NP_006107; NP_705717
	NP_079885
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene.