TAC4

TAC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MOC
Identifiers
Aliases	TAC4, EK, HK-1, HK1, PPT-C, tachykinin 4 (hemokinin), tachykinin 4, tachykinin precursor 4
External IDs	OMIM: 607833; MGI: 1931130; HomoloGene: 89219; GeneCards: TAC4; OMA:TAC4 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,848,069 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,160,091 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; buccal mucosa cell; ; myocardium; ; granulocyte; ; vena cava; ; cerebellar vermis; ; anterior pituitary; ; right lobe of thyroid gland; ; blood; ; left lobe of thyroid gland;
	Top expressed in
	lip; ; pineal gland; ; olfactory epithelium; ; tibiofemoral joint; ; right ventricle; ; skin of abdomen; ; lumbar spinal ganglion; ; aortic valve; ; granulocyte; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; substance P receptor binding; substance K receptor binding; receptor ligand activity;
Cellular component	extracellular region; extracellular space;
Biological process	regulation of blood pressure; inflammatory response; cell-cell signaling; negative regulation of systemic arterial blood pressure; tachykinin receptor signaling pathway; regulation of signaling receptor activity; detection of temperature stimulus involved in sensory perception of pain; regulation of sensory perception of pain; positive regulation of flagellated sperm motility; negative regulation of sensory perception of pain; positive regulation of sensory perception of pain; positive regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	255061
	93670
	ENSG00000176358
	ENSMUSG00000020872
	Q86UU9
	Q99N14
	NM_170685; NM_001077503; NM_001077504; NM_001077505; NM_001077506
	NM_053093
	NP_001070971; NP_001070972; NP_001070973; NP_001070974; NP_733786
	NP_444323
	Wikidata
View/Edit Human	View/Edit Mouse

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1 and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.