TANK (gene)

TANK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KZZ, 1L0A
Identifiers
Aliases	TANK, I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator
External IDs	OMIM: 603893; MGI: 107676; HomoloGene: 3081; GeneCards: TANK; OMA:TANK - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	161,236,230 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	61,654,171 bp
RNA expression pattern
	Top expressed in
	monocyte; ; Achilles tendon; ; germinal epithelium; ; epithelium of nasopharynx; ; bone marrow cells; ; lactiferous duct; ; gallbladder; ; trabecular bone; ; lymph node; ; lower lobe of lung;
	Top expressed in
	granulocyte; ; submandibular gland; ; genital tubercle; ; Paneth cell; ; skin of external ear; ; spleen; ; subcutaneous adipose tissue; ; zygote; ; white adipose tissue; ; tail of embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding; metal ion binding; deubiquitinase activator activity; thiol-dependent deubiquitinase;
Cellular component	cytoplasm; cytosol; protein-containing complex;
Biological process	TRIF-dependent toll-like receptor signaling pathway; signal transduction; positive regulation of ubiquitin-specific protease activity; positive regulation of protein deubiquitination; cellular response to tumor necrosis factor; negative regulation of I-kappaB kinase/NF-kappaB signaling; cellular response to interleukin-1; proteolysis; cellular response to ionizing radiation; cellular response to DNA damage stimulus; I-kappaB kinase/NF-kappaB signaling; viral process;
	Sources:Amigo / QuickGO
Orthologs
	10010
	21353
	ENSG00000136560
	ENSMUSG00000064289
	Q92844; Q6NW12
	P70347
	NM_001199135; NM_004180; NM_133484
NM_001164071; NM_001164072; NM_011529; NM_001355267; NM_001355268;
	NM_001374667; NM_001378922
	NP_001186064; NP_004171; NP_597841; NP_001186064.1
NP_001157543; NP_001157544; NP_035659; NP_001342196; NP_001342197;
	NP_001361596; NP_001365851
	Wikidata
View/Edit Human	View/Edit Mouse

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.