TAS2R1

TAS2R1
Identifiers
Aliases	TAS2R1, T2R1, TRB7, taste 2 receptor member 1
External IDs	OMIM: 604796; MGI: 2681253; HomoloGene: 10480; GeneCards: TAS2R1; OMA:TAS2R1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	9,712,378 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	32,178,440 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; stromal cell of endometrium; ; epithelium of colon; ; placenta; ; caudate nucleus; ; putamen; ; nucleus accumbens; ; hippocampal formation; ; prefrontal cortex;
	Top expressed in
	proximal tubule; ; right kidney; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste;
	Sources:Amigo / QuickGO
Orthologs
	50834
	57254
	ENSG00000169777
	ENSMUSG00000045267
	Q9NYW7
	Q9JKT2
	NM_019599; NM_001386348
	NM_020503
	NP_062545
	NP_065249
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.