TBC1D1

TBC1D1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QYE
Identifiers
Aliases	TBC1D1, TBC, TBC1, TBC1 domain family member 1
External IDs	OMIM: 609850; MGI: 1889508; HomoloGene: 56856; GeneCards: TBC1D1; OMA:TBC1D1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	38,139,175 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	64,508,829 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; body of uterus; ; muscle layer of sigmoid colon; ; right coronary artery; ; ganglionic eminence; ; popliteal artery; ; tibial arteries; ; gastric mucosa; ; left coronary artery; ; ascending aorta;
	Top expressed in
	muscle of thigh; ; spermatocyte; ; zygote; ; retinal pigment epithelium; ; choroid plexus of fourth ventricle; ; granulocyte; ; secondary oocyte; ; right kidney; ; spermatid; ; plantaris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity;
Cellular component	cytosol; nucleus; endomembrane system; intracellular anatomical structure;
Biological process	regulation of cilium assembly; membrane organization; regulation of protein localization; activation of GTPase activity; regulation of vesicle fusion; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	23216
	57915
	ENSG00000065882
	ENSMUSG00000029174
	Q86TI0
	Q60949
NM_001253912; NM_001253913; NM_001253914; NM_001253915; NM_015173;
	NM_001396959
	NM_001289514; NM_019636; NM_001310611
	NP_001240841; NP_001240842; NP_001240843; NP_001240844; NP_055988
	NP_001276443; NP_001297540; NP_062610
	Wikidata
View/Edit Human	View/Edit Mouse

TBC1 domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene.

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and cell differentiation. These proteins share significant homology with TRE2 (USP6), yeast Bub2, and CDC16 (White et al., 2000).[supplied by OMIM]